Polynucleotides are increasingly used in aesthetic medicine due to their regenerative properties, particularly in skin rejuvenation treatments. 

1. Cellular Repair and Regeneration: Polynucleotides can stimulate the repair of damaged skin cells by promoting the growth of fibroblasts, the cells responsible for producing collagen and elastin. This can help improve the skin's overall texture, elasticity, and firmness.

2. Hydration: They have a strong water-binding capacity, which helps to hydrate the skin deeply. This hydration not only makes the skin appear plumper and more radiant but also supports the skin's barrier function, reducing susceptibility to environmental damage.

3. Anti-inflammatory Effects: Polynucleotides have been observed to reduce inflammation in the skin, which can prevent and alleviate symptoms of skin aging and damage caused by inflammatory processes.

4. Stimulating Collagen Production: By promoting collagen synthesis, polynucleotides can help to reduce the appearance of fine lines and wrinkles, leading to smoother and younger-looking skin.

5. Enhancing Skin Recovery: Their ability to promote cell growth and division also aids in the faster recovery of the skin from various types of damage, including sunburn, scars, and other forms of irritation.

In aesthetic practices, polynucleotides are often applied via injections or included in topical formulations. The exact mechanisms are still the subject of ongoing research, but the reported outcomes suggest significant potential in both corrective and preventive skin care.